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胆囊收缩素受体拮抗剂加强大鼠的吗啡镇痛和羟甲芬太尼镇痛

周岩, 孙宇华, 韩济生

北京医科大学神经科学研究中心

摘要

给大鼠脊髓蛛网膜下腔(i.t.)注射100ng高选择性CCK-A受体拮抗剂devazepide或2.5ng CCK-B受体拮抗剂L-365260可显著增强吗啡镇痛(4mg/kg,sc), 两者的剂量效应曲线均为钟形曲线;i.t.注射66 ng devazepide或1.25ng L-365260也能显著增强羟甲芬太尼的镇痛作用(32ng,i.t.),剂量效应曲线亦为钟形曲线。这两种CCK受体拮抗剂本身对痛阈无影响。结果表明, 脊髓内有内源性CCK-8发挥对抗阿片镇痛作用; 鉴于devazepide剂量大于L-365260剂量40—50倍,提示CCK-8在脊髓的抗阿片镇痛功能是通过CCK-B受体实现的。图4参18

关键词： 吗啡镇痛; 羟甲芬太尼镇痛; 八肽胆囊收缩素(CCK-8); 脊髓; CCK受体拮抗剂

Potentiation of morphine-and ohmefentanyl-induced analgesia by cholecystokinin receptor antagonists in rat

Zhou Yan, Sun Yuhua, Han Jisheng

Neurosci. Res. Ctr, Beijing Med. Univ.

Abstract

Key words: Morphine analgesia;Ohmefentanyl analgesia;Cholecystokinin octapeptide;Spinal cord;CCK antagonists

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引用本文：

周岩, 孙宇华, 韩济生. 胆囊收缩素受体拮抗剂加强大鼠的吗啡镇痛和羟甲芬太尼镇痛[J]. 生理学报 1993; 45 (3): .

Zhou Yan, Sun Yuhua, Han Jisheng. Potentiation of morphine-and ohmefentanyl-induced analgesia by cholecystokinin receptor antagonists in rat. Acta Physiol Sin 1993; 45 (3): (in Chinese with English abstract).