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Experimental model systems of primary myelofibrosis

HAN Xu^*, LIU Jing

School of Life Sciences, Department of Hematology of the Second Xiangya Hospital, Central South University, Changsha 410083, China

Abstract

Myeloproliferative neoplasms are a group of clonal proliferative diseases originating from hematopoietic stem cells, with a risk of transformation to acute myeloid leukemia. Primary myelofibrosis (PMF) is a subtype of myeloproliferative neoplasms. Mutations in Janus kinase 2 (JAK2), calreticulin (CALR), and thrombopoietin receptor (MPL) genes are the main pathogenic factors in PMF patients. Current therapeutic strategies, including JAK2 inhibitors, are only effective in a subset of PMF patients, highlighting an urgent need for the development of novel interventions. Experimental models of PMF, including cellular models, animal models, and in vitro organoid models, play crucial roles in exploring pathogenesis and screening potential therapeutic agents. This review comprehensively summarizes these experimental model systems, compares the advantages and disadvantages of different models, and discusses the limitations of current research and prospects for future directions, in order to provide assistance for the development of therapeutic strategies for PMF.

Key words: primary myelofibrosis; experimental model; animal model; pathogenesis; therapeutic strategy

Received: 　　Accepted:

Corresponding author: 韩旭　　E-mail:

DOI: 10.13294/j.aps.2026.0084

Citing This Article：

HAN Xu, LIU Jing. Experimental model systems of primary myelofibrosis. Acta Physiol Sin 2026; 78 (4): 877-888 (in Chinese with English abstract).