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Progress in targeting endogenous neurogenesis for the treatment of ischemic stroke

WANG Meng-Tao¹, DU Hai-Lin², HAO Fei³, HAO Peng^1,*

¹Department of Neurobiology, School of Basic Medicine, Capital Medical University, Beijing 100069, China；²Department of Gastroenterology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China；³Beijing Key Laboratory for Biomaterials and Neural Regeneration, School of Engineering Medicine, Beihang University, Beijing 100191, China

Abstract

Stroke is the leading cause of death and disability in China and the second in the world. A large number of neurons died after ischemic stroke. Due to the limited regenerative capacity of central nervous system, severely restricted neuronal regeneration leads to permanent functional impairment. Therefore, the key to the restoration of ischemic stroke is the regeneration of functional neurons through various strategies. Endogenous neural stem cells are present in the adult central nervous system throughout life and are capable of continuously generating new neurons.This is the intrinsic basis for using endogenous neural stem cells to repair ischemic stroke. Focusing on neuronal regeneration, this review summarizes the changes of endogenous neurogenesis after ischemic stroke. In particular, this review discusses new strategies for the treatment of ischemic stroke by enhancing endogenous repair mechanisms, which provides a theoretical basis for targeting endogenous neurogenesis for the treatment of ischemic stroke.

Key words: ischemic stroke; endogenous neurogenesis; newborn neurons; neurotrophic factors; rehabilitation training; physical therapy; bioactive materials; cell transdifferentiation

Received: 　　Accepted:

Corresponding author: 郝鹏　　E-mail:

DOI: 10.13294/j.aps.2025.0098

Citing This Article：

WANG Meng-Tao, DU Hai-Lin, HAO Fei, HAO Peng. Progress in targeting endogenous neurogenesis for the treatment of ischemic stroke. Acta Physiol Sin 2025; 77 (6): 1071-1085 (in Chinese with English abstract).