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The MAP1 family: a new perspective for exploring unknown functions

WANG Qing, LIU Mei, DONG Zhang-Ji^*

Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong 226001, China

Abstract

As an important part of the cytoskeleton, microtubules play a crucial role in many cellular processes, such as cell division, intracellular transport, and maintaining cell morphology. The MAP1 family is an important family of microtubule-associated proteins, which includes three members: MAP1A, MAP1B, and MAP1S. These proteins are widely involved in the dynamic regulation of the cytoskeleton and play a key role in the development and function of the central nervous system, especially in the development and function of neurons. This study reviews the research progress of the MAP1 family, mainly focusing on the structure and function of MAP1 family members, and paying particular attention to their roles in neuronal development and regeneration, regulatory mechanisms, and neurodegenerative diseases.

Key words: microtubule-associated proteins; MAP1; MAP1A; MAP1B; MAP1S; neurodegenerative diseases

Received: 　　Accepted:

Corresponding author: 董张及　　E-mail:

DOI: 10.13294/j.aps.2025.0062

Citing This Article：

WANG Qing, LIU Mei, DONG Zhang-Ji. The MAP1 family: a new perspective for exploring unknown functions. Acta Physiol Sin 2025; 77 (5): 876-892 (in Chinese with English abstract).