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Research progress in the role of HCN channels in Alzheimer's disease

LI Xiao-Juan^1,2, ZHENG Bo², LAN Ping², ZHANG Wen-Xin², Li Yi-Peng², HE Zhi^2,3,*

¹The Second People's Hospital of China Three Gorges University, Yichang 443000, China；²Basic Medical College, China Three Gorges University, Yichang 443002, China；³School of Medical College, Jiaxing University, Jiaxing 314001, China

Abstract

Alzheimer's disease (AD) is the commonest neurodegenerative disease that causes memory decline, cognitive dysfunction and behavior disorders in the aged people. Primary pathological hallmarks of AD include amyloid-β (Aβ), neurofibrillary tangles (NFTs), gliosis, and neuronal loss. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have important physiological functions, especially in aspects of controlling the resting membrane potential, pacemaker activity, memory formation, sleep and arousal. This article reviews the structure, distribution, regulation of HCN channels and the role of HCN channels in the pathological mechanisms of AD, aiming to provide drug therapeutic targets for the prevention and treatment of AD.

Key words: Alzheimer''s disease; HCN channels; learning and memory; amyloid-β (Aβ)

Received: 　　Accepted:

Corresponding author: 何治　　E-mail:

DOI: 10.13294/j.aps.2025.0078

Citing This Article：

LI Xiao-Juan, ZHENG Bo, LAN Ping, ZHANG Wen-Xin, Li Yi-Peng, HE Zhi. Research progress in the role of HCN channels in Alzheimer's disease. Acta Physiol Sin 2025; 77 (5): 867-875 (in Chinese with English abstract).