Current Issue

Research progress on the role of SIRT1 in heart failure

ZHANG Yang-Min, LYU Mai, WU Chen-Yang, CHEN Yuan-Xi, MA Guo-Lan, LUO An-Tao^*

Institute of Cardiovascular Diseases, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Medicine, Wuhan University of Science and Technology, Wuhan 430065, China

Abstract

Heart failure (HF) is a common end-stage clinical manifestation of cardiovascular diseases, imposing substantial healthrelatedburdens worldwide. With its high mortality rates and poor long-term prognosis, there is a pressing need for novel therapies.SIRT1, a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, has anti-cardiovascular aging properties and other cardioprotectiveeffects, attracting much research attention in recent years. In addition, SIRT1 plays an important role in HF pathophysiology.This review summarized the roles of SIRT1 and its activators in HF, the changes of SIRT1 gene expression in cardiac tissuesfrom animal models and HF patients, and the current status of clinical trials investigating SIRT1 activators as potential therapies forHF. This will provide new ideas for further exploration of pathological mechanisms and the development of clinical prevention strategiesfor HF.

Key words: SIRT1; heart failure; SIRT1 activator; cardiac function; gene expression

Received: 　　Accepted:

Corresponding author: 罗岸涛　　E-mail:

DOI: 10.13294/j.aps.2025.0030

Citing This Article：

ZHANG Yang-Min, LYU Mai, WU Chen-Yang, CHEN Yuan-Xi, MA Guo-Lan, LUO An-Tao. Research progress on the role of SIRT1 in heart failure. Acta Physiol Sin 2025; 77 (2): 361-373 (in Chinese with English abstract).