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Therapeutic potential of ion channel modulation in Alzheimer's disease

HUANG Bin¹, YANG Cheng-Min², LU Zhi-Cheng¹, TANG Li-Na¹, MO Sheng-Long², JIAN Chong-Dong^2,3, SHANG Jing-Wei^2,3,*

¹Graduate School of Youjiang Medical University for Nationalities, Baise 533000, China；²Department of Neurology, the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise 533000, China；³Key Laboratory of Metabolic Diseases in Baise City, Baise 533000, China

Abstract

Alzheimer's disease (AD), a prototypical neurodegenerative disorder, encompasses multifaceted pathological processes. As pivotal cellular structures within the central nervous system, ion channels play critical roles in regulating neuronal excitability, synaptic transmission, and neurotransmitter release. Extensive research has revealed significant alterations in the expression and function of ion channels in AD, implicating an important role of ion channels in the pathogenesis of abnormal Aβ deposition, neuroinflammation, oxidative stress, and disruptions in calcium homeostasis and neural network functionality. This review systematically summarizes the crucial roles and underlying mechanisms of ion channels in the onset and progression of AD, highlighting how these channel abnormalities contribute to AD pathophysiology. We also discuss the therapeutic potential of ion channel modulation in AD treatment, emphasizing the importance of addressing multifactorial nature and heterogeneity of AD. The development of multi-target drugs and precision therapies is proposed as a future direction of scientific research.

Key words: Alzheimer''s disease; therapeutic strategies; ion channel modulation; multi-target drugs; precision medicine

Received: 　　Accepted:

Corresponding author: 商敬伟　　E-mail:

DOI: 10.13294/j.aps.2025.0029

Citing This Article：

HUANG Bin, YANG Cheng-Min, LU Zhi-Cheng, TANG Li-Na, MO Sheng-Long, JIAN Chong-Dong, SHANG Jing-Wei. Therapeutic potential of ion channel modulation in Alzheimer's disease. Acta Physiol Sin 2025; 77 (2): 327-344 (in Chinese with English abstract).