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Research progress of the dopamine system in neurological diseases

NIU Yu-Qi, WANG Jin-Jin, CUI Wen-Fei, QIN Peng, GAO Jian-Feng^*

School of Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China

Abstract

The etiology of nervous system diseases is complicated, posing significant harm to patients and often resulting in poor prognoses. In recent years, the role of dopaminergic system in nervous system diseases has attracted much attention, and its complex regulatory mechanism and therapeutic potential have been gradually revealed. This paper reviews the role of dopaminergic neurons, the neurotransmitter dopamine, dopamine receptors and dopamine transporters in neurological diseases (including Alzheimer's disease, Parkinson's disease and schizophrenia), with a view to further elucidating the disease mechanism and providing new insights and strategies for the treatment of neurological diseases.

Key words: dopamine system; Alzheimer''s disease; Parkinson''s disease; schizophrenia

Received: 　　Accepted:

Corresponding author: 高剑峰　　E-mail:

DOI: 10.13294/j.aps.2025.0025

Citing This Article：

NIU Yu-Qi, WANG Jin-Jin, CUI Wen-Fei, QIN Peng, GAO Jian-Feng. Research progress of the dopamine system in neurological diseases. Acta Physiol Sin 2025; 77 (2): 309-317 (in Chinese with English abstract).