Current Issue

The regulatory effect and mechanism of PGC-1α on mitochondrial function

NAN Song-Hua¹, PENG Chao-Jie¹, CUI Ying-Lin^2,*

¹Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China；²Henan Hospital of Traditional Chinese Medicine, Zhengzhou 450000, China

Abstract

Peroxisome proliferator-activated receptor γ coactivator 1 α (PGC-1α) is a core member of the PGC-1 family and serves as a transcriptional coactivator, playing a crucial regulatory role in various diseases. Mitochondria, the main site of cellular energy metabolism, are essential for maintaining cell growth and function. Their function is regulated by various transcription factors and coactivators. PGC-1α regulates the biogenesis, dynamics, energy metabolism, calcium homeostasis, and autophagy processes of mitochondria by interacting with multiple nuclear transcription factors, thereby exerting significant effects on mitochondrial function. This review explores the biological functions of PGC-1α and its regulatory effects and related mechanisms on mitochondria, providing important information for our in-depth understanding of the role of PGC-1α in cellular metabolism. The potential role of PGC-1α in metabolic diseases, cardiovascular diseases, and neurodegenerative diseases was also discussed, providing a theoretical basis for the development of new treatment strategies.

Key words: PGC-1α; mitochondrion; transcription factors; functional disorders; regulatory mechanism; therapeutic effect

Received: 　　Accepted:

Corresponding author: 崔应麟　　E-mail:

DOI: 10.13294/j.aps.2025.0036

Citing This Article：

NAN Song-Hua, PENG Chao-Jie, CUI Ying-Lin. The regulatory effect and mechanism of PGC-1α on mitochondrial function. Acta Physiol Sin 2025; 77 (2): 300-308 (in Chinese with English abstract).