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Research progress of PANoptosis in cancer

LUO Yi-Ling^1,2, CHEN Liu-Yan^1,2, WANG Yao-Bin^1,2, ZHOU Su-Fang^1,2,*

¹Department of Biochemistry and Molecular Biology, School of Basic Medicine, Guangxi Medical University, Nanning 530021, China；²Key Laboratory of Biological Molecular Medicine Research in Guangxi Medical University, Nanning 530021, China

Abstract

PANoptosis is a type of programmed cell death regulated by the PANoptosome with key features of pyroptosis, apoptosis and/or necroptosis. As the most complex programmed cell death, PANoptosis emphasizes the compensatory role among multiple programmed cell deaths, and can regulate malignant phenotypes such as proliferation, migration, and invasion of tumor cells through multiple signaling pathways, thus affecting malignant tumor progression. It has been found that PANoptosis plays a dual role in tumor progression and treatment. Therefore, it is clinically important to understand the molecular mechanisms by which PANoptosis affects tumorigenesis, development and progression. This paper reviews the molecular mechanisms of apoptosis, pyroptosis and necroptosis, and discusses the activation and regulation mechanisms of PANoptosis and PANoptosome as well as the research progress on the role of PANoptosis in tumors, aiming to provide new ideas for cancer treatment and prognostic assessment.

Key words: Apoptosis; pyroptosis; necroptosis; PANoptosis; PANoptosome; tumor

Received: 　　Accepted:

Corresponding author: 周素芳　　E-mail:

DOI: 10.13294/j.aps.2024.0088

Citing This Article：

LUO Yi-Ling, CHEN Liu-Yan, WANG Yao-Bin, ZHOU Su-Fang. Research progress of PANoptosis in cancer. Acta Physiol Sin 2025; 77 (2): 277-288 (in Chinese with English abstract).