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Research progress of JAK/STAT signaling pathway in rheumatoid arthritis pain

LIU Zhen-Qiang¹, YOU Hao-Jun^1,2, LEI Jing^1,2,*

¹Center for Translational Medicine Research on Sensory-Motor Diseases, Yan'an University, Yan'an 716000, China；²Laboratory of Yan'an Sports Rehabilitation Medicine, Yan'an 716000, China

Abstract

Rheumatoid arthritis (RA) is a common systemic inflammatory autoimmune disease characterized by synovitis and bone destruction. Its clinical characteristics are mainly joint pain, swelling, stiffness and joint deformity. Due to the poor efficacy of both drug and non-drug therapies, RA can significantly impact patients' quality of life and increase personal and socioeconomic burdens. Studies have found that the Janus kinase (JAK)/signal transduction and activator of transcription (STAT) pathway, as classical intracellular signaling pathway, plays an important role in the occurrence and development of connective tissue diseases by regulating inflammation, immunity, and cell differentiation. This article reviews the research progress on the involvement of JAK/STAT signaling pathway in the mechanism of RA pathological pain, in order to provide some reference for understanding the pathogenesis of RA pathological pain and developing specific drug.

Key words: rheumatoid arthritis; JAK/STAT pathway; chronic pain

Received: 　　Accepted:

Corresponding author: 雷静　　E-mail:

DOI: 10.13294/j.aps.2025.0014

Citing This Article：

LIU Zhen-Qiang, YOU Hao-Jun, LEI Jing. Research progress of JAK/STAT signaling pathway in rheumatoid arthritis pain. Acta Physiol Sin 2025; 77 (1): 131-138 (in Chinese with English abstract).