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Research advances on the structure, function, and related diseases of TREK-1 potassium channels

LI Xiao-Ling^1,2,3, LI Yang^4,*, ZHANG Hong¹

¹School of Life Sciences and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China；²Yangtze Delta Drug Advanced Research Institute, Nantong 226133, China；³Aozekang (Nantong) Medical Technology Co., Nantong 226126, China；⁴Shanghai Institute of Pharmacy, Chinese Academy of Sciences, Shanghai 201203, China

Abstract

Two-pore-domain potassium channels (K2P) family is widely expressed in many human cell types and organs, which has important regulatory effect on physiological processes. K2P is sensitive to a variety of chemical and physical stimuli, and they have also been critically implicated in transmission of neural signal, ion homeostasis, cell development and death, and synaptic plasticity. Aberrant expression and dysfunction of K2P channels are involved in a range of diseases, including autoimmune, central nervous system, cardiovascular disease and others. The scope of this review is to give a detailed overview of the structure, function, pharmacological regulation, and related diseases of TREK-1 channels, a member of the K2P family.

Key words: two-pore-domain potassium channels; TREK-1; functional regulation; TREK-1-related diseases

Received: 　　Accepted:

Corresponding author: 李扬　　E-mail:

Citing This Article：

LI Xiao-Ling, LI Yang, ZHANG Hong. Research advances on the structure, function, and related diseases of TREK-1 potassium channels. Acta Physiol Sin 2024; 76 (6): 1043-1055 (in Chinese with English abstract).