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Advances in inhibitory ion channel glycine receptors

PANG Xu-Ke^1,2, CHEN Si^1,2, MA Xiang-Xian^1,2, XU Yi-Nuo³, BAI Wei-Jie⁴, FU Chong-Lei^1,2, ZOU Gui- Chang^5,1,2,*

¹Institute of Brain Science and Brain-inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250117, China；²Shandong Institute of Brain Science and Brain-inspired Research, Jinan 250117, China；³Department of Neurology, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan 250117, China；⁴Department of Neurosurgery, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan 250117, China；⁵Department of Clinical Psychology, Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250117, China

Abstract

Glycine receptors (GlyRs) belong to the ligand-gated ion channel receptor superfamily and are widely distributed throughout the central nervous system. GlyRs are essential for maintaining visual, auditory, sensory and motor functions, and abnormalities in its structure and function can lead to various neurological disorders. This review aims to provide an extensive analysis of the structure, function and regulatory mechanisms of GlyRs, and evaluate its role in various central nervous system diseases. Ultimately, this review will provide theoretical support for the development of novel drugs specifically targeting GlyRs.

Key words: inhibitory ion channel; glycine receptor; nervous system diseases

Received: 　　Accepted:

Corresponding author: 邹桂昌　　E-mail:

Citing This Article：

PANG Xu-Ke, CHEN Si, MA Xiang-Xian, XU Yi-Nuo, BAI Wei-Jie, FU Chong-Lei, ZOU Gui- Chang. Advances in inhibitory ion channel glycine receptors. Acta Physiol Sin 2024; 76 (6): 908-916 (in Chinese with English abstract).