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Research progress on the relationship between TRAF6 and neurodegenerative diseases

LUO Rui-Chang^1,2, WU Xin-Yi^1,2, YU Wen-Wen³, ZHENG Yong-Jian^1,2, WANG Dan^1,2,*

¹Zhejiang Key Laboratory of Silkworm Bioreactor and Biomedicine, Zhejiang Sci-Tech University, Hangzhou 310018, China；²College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China；³Pharmacy Department, Traditional Chinese Medicine Hospital of Yuyao, Yuyao 315400, China

Abstract

Given the increasing trend of aging population in the world, neurodegenerative diseases (NDDs), a common type of diseases that mostly occur in the elderly, have attracted much more attention. It has been shown that tumor necrosis factor receptor-associated factor 6 (TRAF6) is involved in the regulation of neuroinflammation, an important pathological feature of NDDs, and affects the occurrence and development of NDDs. Most importantly, the regulatory effect of TRAF6 is related to its ubiquitination. Therefore, in the present paper, the molecular structure, biological function, and ubiquitination mechanism of TRAF6, and its relationship with some common NDDs, including Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis, were analyzed and summarized. The possible molecular mechanisms by which TRAF6 regulates the occurrence of NDDs were also elucidated, providing a theoretical basis for exploring the etiology and treatment of NDDs.

Key words: tumor necrosis factor receptor-associated factor 6; neurodegenerative diseases; neuroinflammation; ubiquitination

Received: 　　Accepted:

Corresponding author: 王丹　　E-mail:

DOI: 10.13294/j.aps.2024.0041

Citing This Article：

LUO Rui-Chang, WU Xin-Yi, YU Wen-Wen, ZHENG Yong-Jian, WANG Dan. Research progress on the relationship between TRAF6 and neurodegenerative diseases. Acta Physiol Sin 2024; 76 (4): 653-662 (in Chinese with English abstract).