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Research progress on eosinophil heterogeneity in asthma

CHEN Yan^1,2,3, YING Song-Min^1,2, ZHANG Chao^1,2,*

¹Institute of Respiratory Diseases, Zhejiang University, Hangzhou 310030, China；²Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China；³International Institutes of Medicine, Zhejiang University, Yiwu 322000, China

Abstract

Asthma is a heterogeneous disease characterized by chronic airway inflammation. More than half of asthma cases are induced by allergens. Eosinophils accumulate in large numbers in the airways, and their number is closely related to the severity of asthma. In recent years, extensive research has been conducted on the pathogenesis of eosinophils in asthma and the targeted therapeutic drugs for them. This article mainly reviews the research progress on the important role of eosinophil heterogeneity in the occurrence and development of asthma, and provides ideas for the personalized and precise treatment of asthma in the future.

Key words: Asthma; airway inflammation; eosinophil; heterogeneity

Received: 　　Accepted:

Corresponding author: 张超　　E-mail:

DOI: 10.13294/j.aps.2024.0051

Citing This Article：

CHEN Yan, YING Song-Min, ZHANG Chao. Research progress on eosinophil heterogeneity in asthma. Acta Physiol Sin 2024; 76 (4): 643-652 (in Chinese with English abstract).