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Molecular mechanism of CDO1 regulating common metabolic diseases

LIU Qi, SHEN Wen-Qing^*

Key Laboratory of Physiological and Biochemical Testing and Exercise Rehabilitation, School of Physical Education, Anhui Normal University, Wuhu 241002, China

Abstract

Cysteine dioxygenase type 1 (CDO1) belongs to the cysteine dioxygenase (CDO) family. CDO1 is the key enzyme in cysteine catabolism and taurine synthesis. CDO1 is highly expressed in liver, adipose tissue, pancreas, kidney, lung, brain and small intestine. CDO1 is involved in the pathophysiological regulation of various common metabolic diseases, such as lipid metabolism disorders, insulin resistance, obesity, tumors/cancers, and neurodegenerative diseases. This article summarizes the research progress on the molecular mechanisms of CDO1 regulation of common metabolic diseases in recent years, aiming to provide new theoretical and practical basis for CDO1-targeted therapy for insulin resistance, obesity, tumors/cancers, and neurodegenerative diseases.

Key words: CDO1; cysteine; taurine; metabolic diseases

Received: 　　Accepted:

Corresponding author: 沈文清　　E-mail:

DOI: 10.13294/j.aps.2024.0060

Citing This Article：

LIU Qi, SHEN Wen-Qing. Molecular mechanism of CDO1 regulating common metabolic diseases. Acta Physiol Sin 2024; 76 (4): 576-586 (in Chinese with English abstract).