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Research progress on structure, function and disease correlation of solute carrier family 4

DONG Jing^1,2, XU Ya-Li^1,2, MA Yu^1,2, DUAN Xiao-Hong^2,*

¹The College of Life Sciences of Northwest University, Xi’an 710069, China；²State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Disease & Shaanxi Key laboratory of Stomatology, Department of Oral Biology, School of Stomatology, the Fourth Military Medical University, Xi’an 710032, China

Abstract

The solute carrier family 4 (SLC4) includes 10 members (SLC4A1–5, SLC4A7–11), which are expressed in multiple tissues in the human body. The SLC4 family members differ in their substrate dependence, charge transport stoichiometry and tissue expression. Their common function is responsible for the transmembrane exchange of multiple ions, which is involved in many important physiological processes, such as erythrocyte CO2 transport and the regulation of cell volume and intracellular pH. In recent years, many studies have focused on the role of SLC4 family members in the occurrence of human diseases. When SLC4 family members have gene mutations, a series of functional disorders will occur in the body, leading to the occurrence of some diseases. This review summarizes the recent progress about the structures, functions and disease correlation of SLC4 members, in order to provide clues for the prevention and treatment of related human diseases.

Key words: solute carrier family 4; bicarbonate transporter; structure and function; genetic disorder

Received: 　　Accepted:

Corresponding author: 段小红　　E-mail:

DOI: 10.13294/j.aps.2023.0008

Citing This Article：

DONG Jing, XU Ya-Li, MA Yu, DUAN Xiao-Hong. Research progress on structure, function and disease correlation of solute carrier family 4. Acta Physiol Sin 2023; 75 (1): 137-150 (in Chinese with English abstract).