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The role and molecular mechanism of miR-494 in disease development and progression

MO Xia¹, CHEN Ning^1,2, LI Jin-Xiu^1,2, GUO Yan-Ju^3,*, FAN Jing-Jing^1,2

¹College of Health Science, Wuhan Sports University, Wuhan 430079, China；²Hubei Key Laboratory of Exercise Training and Monitoring, Wuhan Sports University, Wuhan 430079, China；³College of Physical Education and Health, Guangxi Normal University, Guilin 541004, China

Abstract

MicroRNA-494 (miR-494) is a small non-coding RNA located in chromosome 14q32.31 and regulates post-transcriptional gene expression by promoting the degradation of its target mRNAs via binding to the 3' untranslated regions (3'UTR). It has been reported that miR-494 plays an important role in the occurrence, development and prognosis of various diseases. Several signaling pathways modulated by miR-494 including the PTEN/PI3K/AKT, nuclear factor κ-B (NF-κB), mitogen-activated protein kinase (MAPK), transforming growth factor-β (TGF-β)/SMAD, and Wnt/β-catenin are associated with physiological regulation and pathological process in many diseases. The stably expression of miR-494 in the blood stream suggests its potential as a biological marker for disease diagnosis, treatment, and prognosis. Based on recent research, we summarize the role and molecular mechanism of miR-494 in disease development and progression. We also discuss its potential as a marker for clinical diagnosis and prognosis of various diseases.

Key words: miR-494; PTEN/PI3K/AKT; nuclear factor κ-B; MAPK; transforming growth factor-β/SMAD; Wnt/β-catenin

Received: 　　Accepted:

Corresponding author: 郭艳菊　　E-mail: guoyj_2520@163.com

DOI: 10.13294/j.aps.2022.0042

Citing This Article：

MO Xia, CHEN Ning, LI Jin-Xiu, GUO Yan-Ju, FAN Jing-Jing. The role and molecular mechanism of miR-494 in disease development and progression. Acta Physiol Sin 2022; 74 (3): 495-504 (in Chinese with English abstract).