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Research progress of lung aging in chronic respiratory diseases

ZHOU Kai¹, CHEN Long², QIN Xiao-Qun¹, XIANG Yang¹, QU Xiang-Ping¹, LIU Hui-Jun¹, LIU Chi^1,*

¹Department of Physiology, School of Basic Medical Science, Central South University, Changsha 410078, China；²Functional Experiment Center, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi 830017, China

Abstract

Cell aging is an extremely complex process, which is characterized by mitochondrial structural dysfunction, telomere shortening, inflammatory microenvironment, protein homeostasis imbalance, epigenetic changes, abnormal DNA damage and repair, etc. Aging is usually accompanied by structural and functional damage of tissues and organs which further induces the occurrence and development of aging-related diseases. Aging includes physiological aging caused by increased age and pathological aging induced by a variety of factors. Noteworthy, as a target organ directly contacting with the outside air, lung is more prone to various stimuli, causing pathological premature aging which is lung aging. Studies have found that there is a certain proportion of senescent cells in the lungs of most chronic respiratory diseases. However, the underlying mechanism by which these senescent cells induce lung senescence and their role in chronic respiratory diseases is still obscure. This paper focuses on the causes and classification of lung aging, the internal mechanism of lung aging involved in chronic respiratory diseases, and the application of anti-aging treatments in chronic respiratory diseases. We hope to provide new research ideas and theoretical basis for the clinical prevention and treatment in chronic respiratory diseases.

Key words: cell senescence; chronic respiratory disease; senescence-associated secretory phenotype (SASP); Senolytic drugs; chimeric antigen receptor (CAR)-T cell therapy

Received: 　　Accepted:

Corresponding author: 刘持　　E-mail: liu.chi@csu.edu.cn

DOI: 10.13294/j.aps.2022.0036

Citing This Article：

ZHOU Kai, CHEN Long, QIN Xiao-Qun, XIANG Yang, QU Xiang-Ping, LIU Hui-Jun, LIU Chi. Research progress of lung aging in chronic respiratory diseases. Acta Physiol Sin 2022; 74 (3): 479-488 (in Chinese with English abstract).