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Histone methylation and diabetic cardiomyopathy

HONG Hao, LI Yu-Meng, MENG Xiang-Min, DENG Tian, ZHU Bing-Mei^*

Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu 610041, China

Abstract

Histone methylation is one of the key post-translational modifications that plays a critical role in various heart diseases, including diabetic cardiomyopathy. A great deal of evidence has shown that histone methylation is closely related to hyperglycemia, insulin resistance, lipid and advanced glycation end products deposition, inflammatory and oxidative stress, endoplasmic reticulum stress and cell apoptosis, and these pathological factors play an important role in the pathogenesis of diabetic cardiomyopathy. In order to provide a novel theoretical basis and potential targets for the treatment of diabetic cardiomyopathy from the perspective of epigenetics, this review discussed and elucidated the association between histone methylation and the pathogenesis of diabetic cardiomyopathy in details.

Key words: epigenetics; histone methylation; diabetic cardiomyopathy

Received: 　　Accepted:

Corresponding author: 朱冰梅　　E-mail: zhubm64@hotmail.com

DOI: 10.13294/j.aps.2022.0045

Citing This Article：

HONG Hao, LI Yu-Meng, MENG Xiang-Min, DENG Tian, ZHU Bing-Mei. Histone methylation and diabetic cardiomyopathy. Acta Physiol Sin 2022; 74 (3): 461-468 (in Chinese with English abstract).