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Exercise regulates lipid metabolism via lipophagy and its molecular mechanisms 

LI Meng-Ying¹, LI Ling-Jie², MA Chun-Wei¹, GAO Bing-Hong^2,*

¹School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China；²School of Physical Training, Shanghai University of Sport, Shanghai 200438, China

Abstract

Lipophagy is a kind of selective autophagy, which can selectively identify and degrade lipid droplets and plays an important role in regulating cellular lipid metabolism and maintaining intracellular lipid homeostasis. Exercise can induce lipophagy and it is also an effective means of reducing body fat. In this review, we summarized the relationship between exercise and lipophagy in the liver, pancreas, adipose tissue, and the possible molecular mechanisms to provide a new clue for the prevention and treatment of fatty liver, obesity and other related metabolic diseases by exercise.

Key words: lipophagy; exercise; obesity; lipid metabolism

Received: 　　Accepted:

Corresponding author: 高炳宏　　E-mail: gaobinghong@126.com

DOI: 10.13294/j.aps.2021.0099

Citing This Article：

LI Meng-Ying, LI Ling-Jie, MA Chun-Wei, GAO Bing-Hong. Exercise regulates lipid metabolism via lipophagy and its molecular mechanisms . Acta Physiol Sin 2022; 74 (2): 309-319 (in Chinese with English abstract).