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Biological function of Nogo-B receptor 

ZHU Ying, ZHANG Li-Qu, LI Jian-Dong^*

Department of Respiratory and Critical Care Medicine, Eighth Medical Center of Chinese PLA General Hospital, Beijing 100091, China

Abstract

Nogo-B receptor (NgBR) is a specific receptor of Nogo-B, a member of reticulon 4 protein family. It is widely expressed in many tissues and mainly located in cell membrane and endoplasmic reticulum. Previous studies have revealed that NgBR is involved in a variety of physiological and pathophysiological processes, such as dolichol synthesis, lipid metabolism, cholesterol trafficking, insulin resistance, vascular remodeling and angiogenesis, tumorigenesis and nervous system diseases. Further studies on the molecular characteristics and biological function of NgBR might be of great significance to understand its role in diverse diseases and provide possible clinical strategies for the treatment of diseases.

Key words: Nogo-B receptor; Nogo-B; NUS1; cholesterol trafficking; tumorigenesis

Received: 　　Accepted:

Corresponding author: 李建东　　E-mail: lijdzyy@163.com

DOI: 10.13294/j.aps.2022.0017

Citing This Article：

ZHU Ying, ZHANG Li-Qu, LI Jian-Dong. Biological function of Nogo-B receptor . Acta Physiol Sin 2022; 74 (2): 301-308 (in Chinese with English abstract).