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Histone deacetylases and acute kidney injury

SHEN Feng-Chen, ZHUANG Shou-Gang^*

Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China

Abstract

Histone acetylation is one of the epigenetic modifications. Histone acetylation, which is catalyzed by histone acetyltransferases and negatively regulated by histone deacetylases, plays an important role in a variety of cellular physiological and pathophysiological processes. Recent studies have shown that histone deacetylases are involved in a variety of pathophysiological responses to acute kidney injury, such as apoptosis, dedifferentiation, proliferation and regeneration. This article reviews the role and underlying mechanism of histone deacetylases in acute kidney injury induced by ischemia reperfusion, nephrotoxicants, sepsis and rhabdomyolysis.

Key words: histone deacetylation; acute kidney injury; ischemia reperfusion; toxic nephrosis; sepsis; rhabdomyolysis

Received: 　　Accepted:

Corresponding author: 庄守纲　　E-mail: szhuang@lifespan.org; gangzhuang@hotmail.com

DOI: 10.13294/j.aps.2022.0013

Citing This Article：

SHEN Feng-Chen, ZHUANG Shou-Gang. Histone deacetylases and acute kidney injury. Acta Physiol Sin 2022; 74 (1): 73-79 (in Chinese with English abstract).