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Exosomal microRNAs: an emerging player in systemic lupus erythematosus 

SHA Xiao-Qi, GE Xing-Yu, JIN Yi, CHEN Tian, JI Juan, GU Zhi-Feng^*

Department of Stomatology, Affiliated Hospital of Nantong University, Nantong 226000, China

Abstract

Exosomes are nanometer-sized membranous extracellular vesicles that can be secreted by almost all types of cells in the body. Exosomes are involved in cell-to-cell communication through autocrine and paracrine forms. Exosomal microRNAs (miRNAs) are stable in plasma, urine and other body fluids, and have various biological functions. They play an irreplaceable role in the occurrence, development, immune regulation of systemic lupus erythematosus (SLE). Recent studies have proposed that exosomal miRNAs have promising application prospects in the pathogenesis, early diagnosis, and treatment of SLE. Therefore, this review aims to introduce the current research progress on exosomal miRNAs in SLE and analyze their potential application value.

Key words: exosomes; microRNAs; immune; systemic lupus erythematosus; lupus nephritis

Received: 2020-12-04　　Accepted: 2021-07-12

Corresponding author: 顾志峰　　E-mail: guzf@ntu.edu.cn

Citing This Article：

SHA Xiao-Qi, GE Xing-Yu, JIN Yi, CHEN Tian, JI Juan, GU Zhi-Feng. Exosomal microRNAs: an emerging player in systemic lupus erythematosus . Acta Physiol Sin 2021; 73 (6): 1035-1042 (in Chinese with English abstract).