Issue Archive

Role of 15-lipoxygenase/15-hydroxyeicosatetraenoic acid in hypoxic pulmonary arterial hypertension

YU Hang¹, MA Cui¹, ZHU Da-Ling^1,2,*

¹Branch Campus of Daqing, Harbin Medical University, Daqing 163311, China；²College of Pharmacy, Harbin Medical University, Harbin 158100, China

Abstract

Pulmonary arterial hypertension (PAH) is a rare disease with a complex aetiology characterized by elevated pulmonary artery resistance, which leads to progressive right ventricular failure and ultimately death. The aberrant metabolism of arachidonic acid in the pulmonary vasculature plays a central role in the pathogenesis of PAH. The levels of 15-lipoxygenase (15-LO) and 15- hydroxyeicosatetraenoic acid (15-HETE) are elevated in the pulmonary arterial endothelial cells (PAECs), pulmonary smooth muscle cells (PASMCs) and fibroblasts of PAH patients. Under hypoxia condition, 15-LO/15-HETE induces pulmonary artery contraction, promotes the proliferation of PAECs and PASMCs, inhibits apoptosis of PASMCs, promotes fibrosis of pulmonary vessels, and then leads to the occurrence of PAH. Here, we review the research progress on the relationship between 15-LO/15-HETE and hypoxic PAH, in order to clarify the significance of 15-LO/15-HETE in hypoxic PAH. 

Key words: hypoxic pulmonary arterial hypertension; 15-lipoxygenase; 15-hydroxyeicosatetraenoic acid; vasoconstriction; vascular remodeling

Received: 2021-01-24　　Accepted: 2021-05-14

Corresponding author: 朱大岭　　E-mail: dalingz@yahoo.com

DOI: 10.13294/j.aps.2021.0058

Citing This Article：

YU Hang, MA Cui, ZHU Da-Ling. Role of 15-lipoxygenase/15-hydroxyeicosatetraenoic acid in hypoxic pulmonary arterial hypertension. Acta Physiol Sin 2021; 73 (4): 646-656 (in Chinese with English abstract).