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Research progress of non-coding RNA in regulating the function of T cells in asthma

HUANG Zhen-Li, XIONG Wei-Ning^*

Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

Abstract

Bronchial asthma (i.e. asthma) is a chronic inflammatory disease characterized by airway inflammatory response, hyperresponsiveness and airway remodeling, in which T cells play a vital role, especially T helper cells (Th cells). Non-coding RNAs (ncRNAs) are the RNAs that do not encode proteins, mainly including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), which are widely found in eukaryotic genomes and participate in the regulation of various biological processes. Previous studies have shown that ncRNAs play an important role in the activation and transformation of T cells and other biological processes in asthma. The specific molecular mechanism and clinical application are worth in-depth discussion. This article reviewed the research progress in regulation of miRNAs, lncRNAs and circRNAs on T cells in asthma in recent years.

Key words: non-coding RNAs; circular RNA; long non-coding RNA; microRNA; asthma; T cells

Received: 2020-04-02　　Accepted: 2020-08-17

Corresponding author: 熊维宁　　E-mail: xiongdoctor@qq.com

DOI: 10.13294/j.aps.2020.0056

Citing This Article：

HUANG Zhen-Li, XIONG Wei-Ning. Research progress of non-coding RNA in regulating the function of T cells in asthma. Acta Physiol Sin 2020; 72 (5): 586-596 (in Chinese with English abstract).