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Ferroptosis in respiratory diseases

CHEN Hai-Xia, WU Yan-Ping, LI Wen, SHEN Hua-Hao, CHEN Zhi-Hua^*

Key Laboratory of Respiratory Diseases of Zhejiang Province, Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China

Abstract

Ferroptosis is a novel form of regulated cell death which is dependent on iron and reactive oxygen species (ROS) and associated with the accumulation of lipid peroxides. It is obviously different from other cell death types in terms of morphology, biochemistry, genetics, etc. Also, it is related to the production of iron catalyzed lipid peroxides which is triggered by non-enzymatic or enzymatic reactions. Ferroptosis has been proved to be involved in hematological diseases, cardio-cerebrovascular diseases, liver and kidney diseases. This paper will review the definition, mechanism, inducers of ferroptosis, as well as the function of ferroptosis   in respiratory system. We expect to present a new concept for respiratory research and suggest potential targets for clinical prevention and treatment of respiratory diseases.

Key words: ferroptosis; respiratory diseases; ferroptosis inducers; lipid peroxides

Received: 2020-04-29　　Accepted: 2020-08-18

Corresponding author: 陈志华　　E-mail: zhihuachen@zju.edu.cn

DOI: 10.13294/j.aps.2020.0064

Citing This Article：

CHEN Hai-Xia, WU Yan-Ping, LI Wen, SHEN Hua-Hao, CHEN Zhi-Hua. Ferroptosis in respiratory diseases. Acta Physiol Sin 2020; 72 (5): 575-585 (in Chinese with English abstract).