Issue Archive

Progress in the mechanisms of response to different oxygen concentrations in Caenorhabditis elegans

HE Ping¹, KANG Na¹, LOU Ping-Ping¹, TU Hai-Jun^1,2,*

¹Institute of Neuroscience, College of Biology, Hunan University, Changsha 410082, China；²Shenzhen Research Institute, Hunan University, Shenzhen 518000, China

Abstract

Oxygen levels are unequal in different living geographical locations of human and related to normal physiology of health. The reduction of oxygen level in the body can lead to a variety of diseases, such as stroke caused by cerebral ischemia and hypoxia. In the recent years, many studies have elucidated the molecular and cellular mechanisms of organism response to different oxygen concentrations by using the nematode Caenorhabditis elegans (C. elegans) as model organism. C. elegans can escape hypoxia or hyperoxia and adapt to the ambient oxygen environments, and there are different response and regulation mechanisms in different degrees of hypoxia environment. In this paper, recent advances in the reaction of nematodes to different oxygen concentrations and the underlying mechanism were reviewed. 

Key words: Caenorhabditis elegans; oxygen concentrations; hypoxia/anoxia; sensitivity and tolerance; cerebral ischemia

Received: 2019-04-07　　Accepted: 2019-05-13

Corresponding author: 涂海军　　E-mail: haijuntu@hnu.edu.cn

DOI: 10.13294/j.aps.2020.0027

Citing This Article：

HE Ping, KANG Na, LOU Ping-Ping, TU Hai-Jun. Progress in the mechanisms of response to different oxygen concentrations in Caenorhabditis elegans. Acta Physiol Sin 2020; 72 (3): 407-417 (in Chinese with English abstract).