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Regulatory mechanism of embryo implantation

GUO Bin^*

College of Veterinary Medicine, Jilin University, Changchun 130062, China

Abstract

Embryo implantation is crucial for the establishment and maintenance of successful pregnancy and requires the synchronization between implantation-competent blastocyst and receptive uterus. In assisted reproductive technologies, recognition of uterine receptivity is the limiting factor for improving pregnancy rate. It has been previously reported that embryo implantation involves the activation and inactivation of numerous signaling molecules which may influence the proliferation and differentiation of uterine epithelial cells, epithelial polarity, luminal closure, embryo orientation, epithelial-stromal interactions, gland development, etc. Here we summarize the function of estrogen, progesterone, leukemia inhibitory factor (LIF), microRNA (miRNA), channel protein and signaling pathways in embryo implantation and explore their regulatory network to provide theoretical basis for the treatment of infertility and development of safe and efficient contraceptives.

Key words: uterine receptivity; embryo implantation; regulatory mechanism

Received: 2019-07-15　　Accepted: 2019-11-25

Corresponding author: 郭斌　　E-mail: guobin79@jlu.edu.cn

DOI: 10.13294/j.aps.2020.0005

Citing This Article：

GUO Bin. Regulatory mechanism of embryo implantation. Acta Physiol Sin 2020; 72 (1): 105-114 (in Chinese with English abstract).