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Role of the system of orexin/receptors in neurological diseases

CUI Jing¹, ZHAO Wei-Yan², CAO Fei¹, XIANG Qian¹, GAO Yan², PAN Yan-You³, WANG Qin-Qin^3,*

¹College of Basic Medicine, Jining Medical University, Jining 272067, China；²School of Mental Health, Jining Medical University, Jining 272067, China；³Neurobiology Institute, Jining Medical University, Jining 272067, China

Abstract

The neuropeptide orexin is widely distributed in the nervous system. Previous studies showed that orexin is involved in the feeding behavior regulation by binding to its receptor 1 (OX1R) and receptor 2 (OX2R) to activate the downstream signaling pathway. Recent studies have demonstrated that the system of orexin and its receptors are also involved in important physiological processes such as sleep-wake, learning and memory, and pathological processes of various neurological diseases. In this review, we summarized the research progress on the function of the orexin and its receptor system in physiological and pathological processes, and revealed the correlation between orexin and nervous system diseases, in order to provide the theoretical guidance for the diagnosis and treatment of the related diseases in the future.

Key words: orexin; orexin receptors; sleep-wake; feeding; memory and cognition; neurological diseases

Received: 2019-01-08　　Accepted: 2019-05-28

Corresponding author: 王琴琴　　E-mail: qqwang@mail.jnmc.edu.cn

DOI: 10.13294/j.aps.2019.0050

Citing This Article：

CUI Jing, ZHAO Wei-Yan, CAO Fei, XIANG Qian, GAO Yan, PAN Yan-You, WANG Qin-Qin. Role of the system of orexin/receptors in neurological diseases. Acta Physiol Sin 2019; 71 (4): 657-670 (in Chinese with English abstract).