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Macrophages polarization and their role in chronic obstructive pulmonary disease

LI Yin¹, LU Jing¹, ZHANG Yi¹, CHENG Chen¹, LIU Zi-Bing^2,*

¹Graduate School, Anhui University of Chinese Medicine, Hefei 230012, China；²Acupuncture and Tuina College, Anhui University of Chinese Medicine, Hefei 230012, China

Abstract

Macrophages are highly plastic and can be polarized into classical activated macrophages (M1) and alternative activated macrophages (M2) under the induction of inflammatory factors and regulation of a variety of information molecules. Chronic pulmonary inflammation and pulmonary parenchyma injury are the main pathological manifestations of chronic obstructive pulmonary disease (COPD). M1 promotes pulmonary inflammation, whereas M2 inhibits inflammatory response, participates in lung tissue injury and repair, and swallows and removes pathogenic microorganisms and apoptotic cells. Target intervention in the polarization direction of macrophages may be a new strategy for COPD treatment.

Key words: Macrophages; macrophages polarization; chronic obstructive pulmonary disease

Received: 2018-12-17　　Accepted: 2019-04-08

Corresponding author: 刘自兵　　E-mail: zibingliu@163.com

DOI: 10.13294/j.aps.2019.0055

Citing This Article：

LI Yin, LU Jing, ZHANG Yi, CHENG Chen, LIU Zi-Bing. Macrophages polarization and their role in chronic obstructive pulmonary disease. Acta Physiol Sin 2019; 71 (4): 604-612 (in Chinese with English abstract).