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The role of stem cell-derived exosomes in repairing myocardial injury

LIN Chao-Jin, LI Song-Pei, DENG Sai, FU Xiao-Mei, QIN Ai-Ping, YU Xi-Yong^*

School of Pharmaceutical Sciences of Guangzhou Medical University, Guangdong Key Laboratory of Molecular Target & Clinical Pharmacology, State Key Laboratory of Respiratory Diseases Pharmacology Group, Guangzhou 511436, China

Abstract

At present, it is generally believed that the paracrine effect of stem cells in the repair of myocardial injury is one of the 

important ways for stem cell therapy. Exosomes are phospholipid bilayer-enclosed nanovesicles that secreted by cells under physiological and pathological conditions. Cargo loaded into exosomes including protein, lipids and nucleic acids can be delivered to recipient cells. Therefore, exosomes are recognized as important mediators for intercellular communication. It has been suggested that exosomes from stem cells (eg. embryonic stem cells, induced pluripotent stem cells, cardiac progenitor cells, mesenchymal stem cells and cardiosphere-derived cells) have protective effects against heart injury. In this review, we summarized recent research progresses on stem cell-derived exosomes in myocardial injury, including the therapeutic effects and mechanism.

Key words: Stem cells; exosomes; myocardial injury repair

Received: 2018-08-13　　Accepted: 2018-12-13

Corresponding author: 余细勇　　E-mail: yuxycn@aliyun.com

DOI: 10.13294/j.aps.2019.0010

Citing This Article：

LIN Chao-Jin, LI Song-Pei, DENG Sai, FU Xiao-Mei, QIN Ai-Ping, YU Xi-Yong. The role of stem cell-derived exosomes in repairing myocardial injury. Acta Physiol Sin 2019; 71 (2): 205-215 (in Chinese with English abstract).