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Hyperhomocysteinemia and kidney diseases

ZHOU Yun-Feng¹, GUAN You-Fei^2,*

¹Medical Research Center, Physiology Department of Basic Medical College, Shenzhen University Health Science Center, Shenzhen 518060, China；²Advanced Institute of Medical Sciences, Dalian Medical University, Dalian 116044, China

Abstract

Homocysteine (Hcy) is an intermediate metabolite of methionine metabolism. Hyperhomocysteinemia (HHcy) is defined as a condition characterized by plasma Hcy level above 16 μmol/L which can result from abnormal Hcy metabolism. HHcy has been confirmed to be related to cardio-cerebrovascular disease, peripheral vascular disorders, neurodegenerative diseases, diabetes, pregnancy-induced hypertension syndrome, liver cirrhosis and kidney diseases. In this review, we summarize the correlation between HHcy and kidney diseases. Elucidating the role of HHcy in kidney diseases may provide a new strategy to prevent and treat kidney diseases.

Key words: Homocysteine; hyperhomocysteinemia; kidney diseases

Received: 2018-08-09　　Accepted: 2018-11-12

Corresponding author: 管又飞　　E-mail: guanyf@dmu.edu.cn

DOI: 10.13294/j.aps.2018.0087

Citing This Article：

ZHOU Yun-Feng, GUAN You-Fei. Hyperhomocysteinemia and kidney diseases. Acta Physiol Sin 2018; 70 (6): 607-611 (in Chinese with English abstract).