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New advances in renal mechanisms of high fructose-induced salt-sensitive hypertension

XU Chuan-Ming^1,2, YANG Tian-Xin^1,2,*

¹Institute of Hypertension, Sun Yat-sen University School of Medicine, Guangzhou 510080, China；²Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah, USA

Abstract

Fructose intake has increased dramatically over the past century and the upward trend has continued until recently. Increasing evidence suggests that the excessive intake of fructose induces salt-sensitive hypertension. While the underlying mechanism is complex, the kidney likely plays a major role. This review will highlight recent advances in the renal mechanisms of fructose-induced salt-sensitive hypertension, including (pro)renin receptor-dependent activation of intrarenal renin-angiotensin system, increased nephron Na+ transport activity via sodium/hydrogen exchanger 3 and Na/K/2Cl cotransporter, increased renal uric acid production, decreased renal nitric oxide production, and increased renal reactive oxygen species production, and suggest actions based on these mechanisms that have therapeutic implications.

Key words: fructose; salt-sensitive hypertension; intrarenal renin-angiotensin system; (pro)renin receptor; nephron ion transporter; uric acid; nitric oxide; reactive oxygen species;

Received: 2018-06-05　　Accepted: 2018-11-26

Corresponding author: 杨天新　　E-mail: tianxin.yang@hsc.utah.edu

DOI: 10.13294/j.aps.2018.0088

Citing This Article：

XU Chuan-Ming, YANG Tian-Xin. New advances in renal mechanisms of high fructose-induced salt-sensitive hypertension. Acta Physiol Sin 2018; 70 (6): 581-590