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Research progress on microRNAs involved in vascular development

CHEN Qi¹, XU Qiang-Hua^1,2,3,4,*

¹College of Marine Sciences, Shanghai Ocean University, Shanghai 201306, China；²Key Laboratory of Sustainable Exploitation of Ocean Fisheries Resources, Ministry of Education, Shanghai 201306, China；³National Distant-water Fisheries Engineering Research Center, Shanghai 201306, China；⁴Collaborative Innovation Center for Distant-water Fisheries, Shanghai 201306, China

Abstract

The vertebrate vascular system development is a very important and complicated process. MicroRNAs regulate gene expression at transcriptional and post-transcriptional levels and play important roles in many physiological and pathological processes. MicroRNAs mainly participate in the regulation of vascular smooth muscle cell and vascular endothelial cell development. In this paper, we summarize the recent progress regarding the microRNAs involved in the vascular development. In particular, we focus on the microRNAs including miR-126, miR-17/92 family in endothelial cell’s regulation, and miR-143/145 family, miR-21 in vascular smooth muscle cell’s regulation. The future research on the role of microRNAs in vascular development is also prospected.  

Key words: vascular development; microRNAs; regulation

Received: 2018-03-07　　Accepted: 2018-09-20

Corresponding author: 许强华　　E-mail: qhxu@shou.edu.cn

DOI: 10.13294/j.aps.2018.0062

Citing This Article：

CHEN Qi, XU Qiang-Hua. Research progress on microRNAs involved in vascular development. Acta Physiol Sin 2018; 70 (5): 548-556 (in Chinese with English abstract).