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Regulation of iron metabolism by hypoxia-inducible factors

XU Man-Man, Wang Jun, XIE Jun-Xia^*

Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders, Medical College of Qingdao University, Qingdao 266071, China

Abstract

Hypoxia-inducible factors (HIFs) are central mediators of cellular adaption to hypoxia. The heterodimeric HIF transcription factors consist of HIF-α and HIF-β, that form functional HIFs. Mammals contain HIF-1α, HIF-2α, and HIF-3α. HIFs play a key role in iron metabolism by regulating the expression of iron-related proteins, such as divalent metal transporter 1 (DMT1), ferroportin 1 (FPN1), duodenal cytochrome b (Dcytb), and transferrin receptor (TfR). Hepcidin and iron regulatory proteins (IRPs), the central mediators for systematic and intracellular iron homeostasis, are also regulated by HIFs. In this review, we summarized the regulatory effects of HIFs on iron-related proteins, thus providing insights into the control of HIFs as therapeutic strategies for some iron related disorders.

Key words: hypoxia-inducible factors; iron metabolism ; divalent metal transporter 1 ; ferroportin 1

Received: 2017-04-25　　Accepted: 2017-08-25

Corresponding author: 谢俊霞　　E-mail: jxiaxie@public.qd.sd.cn

DOI: 10.13294/j.aps.2017.0054

Citing This Article：

XU Man-Man, Wang Jun, XIE Jun-Xia. Regulation of iron metabolism by hypoxia-inducible factors . Acta Physiol Sin 2017; 69 (5): 598-610 (in Chinese with English abstract).