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Cannabinoid receptor system regulates ion channels and synaptic transmission in retinal cells

WANG Shao-Liu¹, QIAN Wen-Jing², WANG Xiao-Han², WANG Shu-Yue², YANG Wei², ZHANG Chuan-Qiang², WANG Zhong-Feng^2,*

¹Luoyang Vocational and Technical College, Luoyang 471000, China；²Institutes of Brain Science, State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China

Abstract

Endocannabinoid receptor system is extensively expressed in the vertebrate retina. There are two types of cannabinoid receptors, CB1 and CB2. Activation of these two receptors by endocannabinoids N-arachidonoylethanolamide (anandamine, AEA) and 2-arachidonyl glycerol (2-AG) regulates multiple neuronal and glial ion channels, thus getting involved in retinal visual information processing. In this review, incorporating our results, we discuss the modulation of cannabinoid CB1 and CB2 receptors on retinal neuronal and glial ion channels and retinal synaptic transmission.

Key words: CB1 receptor; CB2 receptor ; retina ; voltage-gated Ca2+ channels ; K+ channels ; synaptic transmission

Received: 2017-04-19　　Accepted: 2017-09-11

Corresponding author: 王中峰　　E-mail: zfwang@fudan.edu.cn

DOI: 10.13294/j.aps.2017.0064

Citing This Article：

WANG Shao-Liu, QIAN Wen-Jing, WANG Xiao-Han, WANG Shu-Yue, YANG Wei, ZHANG Chuan-Qiang, WANG Zhong-Feng. Cannabinoid receptor system regulates ion channels and synaptic transmission in retinal cells. Acta Physiol Sin 2017; 69 (5): 685-692 (in Chinese with English abstract).