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Effects of integrin on differentiation of mesenchymal stem cells

SHAN Hai-Yan, ZHANG Lei

Biomedical Research Center, Affiliated Calmette Hospital of Kunming Medical University (First Hospital of Kunming), Kunming 650011, China

Abstract

Integrin is a family of transmembrane heterodimer receptor formed by α and β two subunits, which transduces external signals into cells through reaction with extracellular matrix and is crucial to cell survival, migration, and differentiation. With the deep studies on multipotential differentiation of mesenchymal stem cells (MSCs), researchers found that the differentiation of MSCs depends on integrin related signaling pathways, including MAPK, Wnt and PI3K signaling pathways and so on. However, there are many factors affecting the expression and activation of integrin, such as nano morphology microenvironment, ascorbic acid, bone morphogenetic protein-2, fibronectin, cadherin, fluid shear stress and so on. In this review, we mainly discuss the integrin expression, the promoting effects of integrin on the differentiation of MSCs and their underlying mechanisms.

Key words: integrin; mesenchymal stem cells ; signaling pathway; cell differentiation

Received: 2017-02-21　　Accepted: 2017-05-25

Corresponding author: 张蕾　　E-mail: zlei01@hotmail.com

Citing This Article：

SHAN Hai-Yan, ZHANG Lei. Effects of integrin on differentiation of mesenchymal stem cells. Acta Physiol Sin 2017; 69 (4): 498-508 (in Chinese with English abstract).