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[Neuroprotective role of silent information regulator 1 in Alzheimer's disease.] [Article in Chinese]

YANG Xiao-Rong, WANG Rui, QIN Hua-Ping, ZHAO Xin, LIU Nai-Hong, ZHANG Ce^*

Department of Physiology, National Key Disciplines, Key Laboratory for Cellular Physiology of Ministry of Education, Shanxi Medical University, Taiyuan 030001, China

Abstract

Silent information regulator 1 (SIRT1), an NAD+-dependent deacetylase, is involved in the regulation of gene transcription, energy metabolism and cell aging. Recent studies have showed that SIRT1 possesses neuroprotective effects, however, it is not very clear how SIRT1 exerts the neuroprotection in Alzheimer’s disease (AD). In this review, we summarized the neuroprotective role of SIRT1 in AD and its possible molecular mechanisms, proposing a novel strategy for preventing and treating neurodegeneration.

Key words: silent information regulator 1; Alzheimer's disease; neuroprotection

Received: 2011-03-08　　Accepted: 2011-05-16

Corresponding author: 张策　　E-mail: cezh2002@yahoo.com

Citing This Article：

YANG Xiao-Rong, WANG Rui, QIN Hua-Ping, ZHAO Xin, LIU Nai-Hong, ZHANG Ce. [Neuroprotective role of silent information regulator 1 in Alzheimer's disease.] [Article in Chinese]. Acta Physiol Sin 2011; 63 (4): 396-400 (in Chinese with English abstract).