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[Effects of SUMOylation on the subcellular localization and function of DAXX.] [Article in Chinese]

Li Ling, WEN Juan, TUO Qin-Hui, LIAO Duan-Fang

Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421001, China； School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China

Abstract

Death domain-associated protein (DAXX) as a multifunctional nuclear protein widely resides in nucleolus, nucleoplasm, chromatin, promyelocytic leukaemia nuclear bodies (PML-NBs) and cytoplasm. It plays significant roles in transcriptional regulation, apoptosis, cell cycle and other biological activities. Small ubiquitin-like modifier (SUMO) is required for SUMOylation which is a highly conserved post-translational modification in a wide variety of cellular processes. Numerous studies demonstrated that SUMOylation has a great effect on the subcellular localization and functional regulation of DAXX. This review will provide a summary for SUMOylation of DAXX.

Key words: small ubiquitin-like modifier; death domain-associated protein; subcellular localization; SUMOylation

Received: 2012-05-10　　Accepted: 2012-08-20

Corresponding author: 庹勤慧　　E-mail: qhtuo@yahoo.com.cn

Citing This Article：

Li Ling, WEN Juan, TUO Qin-Hui, LIAO Duan-Fang. [Effects of SUMOylation on the subcellular localization and function of DAXX.] [Article in Chinese]. Acta Physiol Sin 2013; 65 (1): 89-95 (in Chinese with English abstract).