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Oxytocin system in neuropsychiatric disorders: Old concept, new insights

MISRANI Afzal, TABASSUM Sidra, LONG Cheng

School of Life Sciences； Institue of Brain Science, South China Normal University, Guangzhou 510631, China

Abstract

Oxytocin (OXT) is a neuropeptide that plays a pivotal role among species peripherally and centrally. It recently has attracted much attention for its involvement in anxiety-related behavior, stress regulation, social behavior and various neuropsychiatric disorders. OXT is one of the important mediators of emotional and social behaviors such as maternal behavior, fear extinction, social support, happiness, and trust. It is also involved in learning and memory process. The recent progresses in OXT system have put this neuropeptide as an important psychotherapeutic intervention for various psychiatric disorders such as stress, anxiety disorders, social phobia, postpartum depression, bipolar disorder, autism, and schizophrenia. In this review, we highlight OXT’s contributions to various physiological functions and psychological disorders and discuss its potential use as a therapeutic agent.

Key words: Oxytocin; stress ; anxiety ; fear ; autism ; schizophrenia

Received: 2016-08-04　　Accepted: 2016-10-28

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Citing This Article：

MISRANI Afzal, TABASSUM Sidra, LONG Cheng. Oxytocin system in neuropsychiatric disorders: Old concept, new insights. Acta Physiol Sin 2017; 69 (2): 196-206