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Changes in biological functions of high-density lipoprotein after abnormal modification

QU Hang, YU Yang, QIN Shu-Cun, SONG Guo-Hua

Key Laboratory of Atherosclerosis in Universities of Shandong and Institute of Atherosclerosis； College of Basic Medicine, Taishan Medical University, Taian 271000, China

Abstract

High-density lipoprotein (HDL) is composed of apolipoproteins, lipids and functional proteins. HDL protects against atherosclerosis (AS) by reverse cholesterol transport (RCT). HDL inhibits the lipid oxidation, inflammation and restores endothelial function. During systemic inflammation or metabolic disorders, HDL can be modified abnormally and converted to a dysfunctional type, which results in the loss of anti-inflammatory factors including apolipoprotein A-I (apoA-I), paraoxonase (PON) and platelet activating factor acetylhydrolase (PAF-AH), and gains of pro-inflammatory factors such as serum amyloid A (SAA), triglyceride (TG) and oxidative lipid. Therefore, understanding the changes in compositions and biological functions of dysfunctional HDL might help to comprehend its pathogenic mechanism.

Key words: dysfunctional high-density lipoprotein; high-density lipoprotein ; inflammation; lipid ; lipoprotein

Received: 2016-11-08　　Accepted: 2017-01-17

Corresponding author: 秦树存,宋国华　　E-mail: 18653862698@163.com,shucunqin@hotmail.com

Citing This Article：

QU Hang, YU Yang, QIN Shu-Cun, SONG Guo-Hua . Changes in biological functions of high-density lipoprotein after abnormal modification. Acta Physiol Sin 2017; 69 (2): 225-234 (in Chinese with English abstract).