Issue Archive

[Role of endoplasmic reticulum-plasma membrane junctions in intracellular calcium homeostasis and cardiovascular disease.] [Article in Chinese]

ZHAO Ming, JIA Hang-Huan, XU Man, YU Xiao-Jiang, LIU Long-Zhu, ZANG Wei-Jin^*

Department of Pharmacology, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China

Abstract

Calcium overload is one of the important mechanisms of cardiovascular disease. Endoplasmic reticulum is an important organelle which regulates intracellular calcium homeostasis by uptake, storage and mobilization of calcium. So it plays a critical role in regulation of intracellular calcium homeostasis. Endoplasmic reticulum, which is widely distributed in cytoplasm, has a large number of membrane junction sites. Recent studies have reported that these junction sites are distributed on plasma membrane and organelle membranes (mitochondria, lysosomes, Golgi apparatus, etc.), separately. They could form complexes to regulate calcium transport. In this review, we briefly outlined the recent research progresses of endoplasmic reticulum-plasma membrane junctions in intracellular calcium homeostasis and cardiovascular disease, which may offer a new strategy for prevention and treatment of cardiovascular disease.

Key words: endoplasmic reticulum-plasma membrane junctions; cardiovascular disease; protein-protein complex; calcium overload; intracellular calcium homeostasis

Received: 2016-02-25　　Accepted: 2016-05-04

Corresponding author: 臧伟进　　E-mail: zwj@mail.xjtu.edu.cn

Citing This Article：

ZHAO Ming, JIA Hang-Huan, XU Man, YU Xiao-Jiang, LIU Long-Zhu, ZANG Wei-Jin. [Role of endoplasmic reticulum-plasma membrane junctions in intracellular calcium homeostasis and cardiovascular disease.] [Article in Chinese]. Acta Physiol Sin 2016; 68 (4): 517-524 (in Chinese with English abstract).