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Physiological regulation of hematopoietic stem cell and its molecular basis

Dong Fang, HAO Sha, CHENG Hui, CHENG Tao

State Key Laboratory of Experimental Hematology, Institute of Hematology &； Blood Diseases Hospital, Chinese Academy of Medical Sciences &； Peking Union Medical College, Tianjin 300020, China； Center for Stem Cell Medicine, Chinese Academy of Medical Sciences, Tianjin 300020, China

Abstract

As a classical type of tissue stem cells, hematopoietic stem cell (HSC) is the earliest discovered and has been widely applied in the clinic as a great successful example for stem cell therapy. Thus, HSC research represents a leading field in stem cell biology and regenerative medicine. Self-renewal, differentiation, quiescence, apoptosis and trafficking constitute major characteristics of functional HSCs. These characteristics also signify different dynamic states of HSC through physiological interactions with the microenvironment cues in vivo. This review covers our current knowledge on the physiological regulation of HSC and its underlying molecular mechanisms. It is our hope that this review will not only help our colleagues to understand how HSC is physiologically regulated but also serve as a good reference for the studies on stem cell and regenerative medicine in general.

Key words: hematopoietic stem cell; Self-renewal; differentiation; quiescence; apoptosis; trafficking

Received: 2016-03-25　　Accepted: 2016-06-02

Corresponding author: 程涛　　E-mail: chengtao@ihcams.ac.cn

Citing This Article：

Dong Fang, HAO Sha, CHENG Hui, CHENG Tao. Physiological regulation of hematopoietic stem cell and its molecular basis. Acta Physiol Sin 2016; 68 (4): 423-434 (in Chinese with English abstract).