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Research progress of relationship between exosomes and breast cancer

BI Tao-Ling, SUN Jin-Jian, TIAN Yu-Zi, ZHOU Ye-Fang^*

Department of Cellular Biology, School of Life Sciences, Central South University &； State Key Laboratory of Medical Genetics, Changsha 410108, China

Abstract

Exosomes are nanosized small membrane microvesicles of endocytic origin secreted by most cell types. Exosomes, through its carrying protein or RNA from derived cells, affect gene regulation networks or epigenetic reorganization of receptor cell, and then modulate the physiological processes of cells. Studies have shown that external exosomes secreted by breast cancer cells or other cells play an important role in the development of tumor, including cell migration, cell differentiation and the immune response, etc. In this article, the latest studies were summarized to provide an overview of current understanding of exosomes in breast cancer.

Key words: exosome; breast cancer; cell migration; cell differentiation; immune response

Received: 　　Accepted:

Corresponding author: 周叶方　　E-mail: zhouyefang191@126.com

Citing This Article：

BI Tao-Ling, SUN Jin-Jian, TIAN Yu-Zi, ZHOU Ye-Fang. Research progress of relationship between exosomes and breast cancer. Acta Physiol Sin 2016; 68 (3): 352-358 (in Chinese with English abstract).