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[Role of eukaryotic translation initiation factor 4G in tumor.] [Article in Chinese]

ZHANG Si, HUANG Nan, PAN Xia, ZANG Jing-Lei, GUAN Xin-Xin, ZHANG Jian-Hua, LIU Liu-Cheng, LEI Xiao-Yong^*

Institute of Pharmacy and Pharmacology, University of South China, Hengyang 421000, China

Abstract

Eukaryotic translation initiation factor 4G (eIF4G) is a scaffold component of eukaryotic translation initiation factor 4F (eIF4F) complex, which takes principal part in the initiating of protein synthesis. Both two subtypes (eIF4G1 and eIF4G2) of eIF4G were found to be closely related with various tumors. The eIF4G1 expression is significantly up-regulated in breast cancer, cervical cancer, nasopharyngeal carcinoma, lung squamous cell carcinoma, prostatic carcinoma and other malignant tumors, compared with those in adjacent tissues; and the eIF4G2 is obviously over-expressed in diffuse large B cell lymphoma and acute myeloid leukemia, but low-expressed in bladder transitional cell carcinoma. This paper reviews the progress in the study of the role of eIF4G in tumor genesis, development, diagnosis and prognosis.

Key words: eukaryotic translation initiation factor 4G (eIF4G); eIF4G1; eIF4G2; tumor

Received: 2015-11-20　　Accepted: 2016-02-17

Corresponding author: 雷小勇　　E-mail: 1622214323@qq.com

Citing This Article：

ZHANG Si, HUANG Nan, PAN Xia, ZANG Jing-Lei, GUAN Xin-Xin, ZHANG Jian-Hua, LIU Liu-Cheng, LEI Xiao-Yong. [Role of eukaryotic translation initiation factor 4G in tumor.] [Article in Chinese]. Acta Physiol Sin 2016; 68 (2): 207-214 (in Chinese with English abstract).