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Ginkgolide B inhibits carotid sinus baroreflex in anesthetized male rats

Wang Chunyan, Wu Yuming, Xiao Lin, Xue Hongmei, Wang Ru, Wang Fuwei, He Ruirong

Department of Physiology, Institute of Basic Medicine, Hebei Medical University.Shijiazhuang 050017,Hebei

Abstract

The effects of ginkgolide B on the carotid sinus baroreflex （CSB） were studied in the perfused isolated carotid sinus of 30 anesthetized Sprague-Dawley male rats. The results were as follows. （1） By perfusing with ginkgolide B （0.1, 1, 10 #mu#mol/L）, the functional curve of the baroreflex was shifted to the right and upward. There was a marked decrease in peak slope （PS） and reflex decrease （RD） in mean arterial pressure （P〈0.01）, while the threshold pressure （TP）, equilibrium pressure （EP） and saturation pressure （SP） were significantly increased （P〈0.05, P〈0.01）. Among the functional parameters of CSB, the changes in PS, RD, TP, EP and SP were dose-dependent. （2） Pretreatment with Bay K8644 （500 nmol/L）, an agonist of L-type calcium channel, completely eliminated the effects of ginkgolide B （1 #mu#mol/L） on the CSB. （3） Pretreatment with tetraethylammonium （TEA, 1 mmol/L）, an inhibitor of potassium channel, completely abolished the above effects of ginkgolide B （1 #mu#mol/L） on the CSB. These results suggest that ginkgolide B inhibits the CSB in anesthetized rats, which is mediated by decreased calcium influx and increased potassium efflux in baroreceptor nerve endings.

Key words: ginkgolide B;Carotid sinus;baroreflex;tetraethylammonium

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Citing This Article：

Wang Chunyan, Wu Yuming, Xiao Lin, Xue Hongmei, Wang Ru, Wang Fuwei, He Ruirong. Ginkgolide B inhibits carotid sinus baroreflex in anesthetized male rats. Acta Physiol Sin 2008; 60 (1): 17-22 (in Chinese with English abstract).