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Phospholipid scramblase 1

Huang Ying, Zhao Qian, Chen Guoqiang

Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education of China, Shanghai Jiaotong University School of Medicine.Shanghai 200025

Abstract

Phospholipid scramblase 1 （PLSCRI） is a calcium-binding, multiply palmitoylated type Ⅱ endofacial plasma membrane protein, while unpalmitoylated PLSCR1 protein can import into the nucleus, where it binds to genomic DNA. Although the original work showed that PLSCRI contributes to the transbilayer movement of phospholipids, the following studies revealed that PLSCRI expression can be induced by some cytokines such as interferon, epidermal growth factor, and also by leukemic cell differentiationinducing agents such as all-trans retinoic acid （ATRA） and phorbol 12-myristate 13-acetate （PMA）. PLSCRI was also shown to interact with several protein kinases including c-Abl, c-Src, protein kinase C#delta# as well as some other proteins such as onzin, suggesting the roles of PLSCR1 in cell signaling. Indeed, the current evidence proposes that PLSCRI contributes to cell proliferation, differentiation, apoptosis, and plays roles in the pathogenesis of cancers, especially leukemia.

Key words: phospholipid scramblase 1;leukemia

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Citing This Article：

Huang Ying, Zhao Qian, Chen Guoqiang. Phospholipid scramblase 1. Acta Physiol Sin 2006; 58 (6): (in Chinese with English abstract).