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Developmental regulation of intracellular calcium homeostasis in early cardiac myocytes

Fu Jidong, Yang Huangtian

Key Laboratory of Stem Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences.Shanghai 200025

Abstract

The proper intracellular Ca~(2+) signaling is essential for normal cell functions and organ development, and the maintaining Ca~(2+) homeostasis in cardiac myocytes is of functional importance for the intact heart. As the first functional organ in the vertebrate embryo, the heart is continuously remodeled and maintains its physiologic pumping function in response to increasing circulatory demands. The expressions of Ca~(2+) handing proteins in the embryonic heart, however, are different from those in neonatal and adult hearts, which means that the regulation of Ca~(2+) transients in embryonic cardiomyocytes is different from that in adult cardiac myocytes. Recent advances in molecular and cellular biology, as well as the application of embryonic stem cell differentiation system, have made progress in uncovering the regulation of Ca~(2+) homeostasis during cardiomyogenesis. This paper briefly summarizes the Ca~(2+) homeostasis during early development of cardiomyocytes and reviews current knowledge of the regulatory mechanisms controlling Ca~(2+) homeostasis during cardiomyocyte development.

Key words: Ca~(2+) homeostasis;Cardiomyocytes;development

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Citing This Article：

Fu Jidong, Yang Huangtian. Developmental regulation of intracellular calcium homeostasis in early cardiac myocytes. Acta Physiol Sin 2006; 58 (2): (in Chinese with English abstract).