Abstract
he role of basolateral amygdaloid nuclei (BLN) in sleep and wakeful state (W)was investigated with polysomnography. Electrical lesion of bilatend BLN increased slow wave sleep (SWS) and paradoxical sleep (PS), but decreased W. Bilateral injection of kainic acid (KA), which selectively destroyed the soma of neurons, resulted in biphasic effects-At d 1 after KA, insmmia occurred. At d 4, SWS increased while W decreased,but PS did not change. Unilateral injection of NO donor sodium nitroferricyanide (SNP)caused an enhanement of W and a decrease of SWS. Injection of nitric oxide synthase inhibitor N-nitro-L-arginine (L-NNA) led to opposite effects. L-arginine, a precursor of NO, had no direct effect on sleep and W, but blocked the effects of L-NNA.The results suggest.-that BLN plays an important rofe in regulating sleep and wakeful state.Destruction of BLN increases SWS, and NO in BLN has W-prornoting and SWS-inhibiting effects, which may be mediated by activation of neurons in BLN.
Received: Accepted:
Corresponding author: E-mail:
Citing This Article：
, , , , , , . . Acta Physiol Sin 1998; 50 (6): (in Chinese with English abstract).
Copyright © 1927-2022 Acta Physiologica Sinica All Rights Reserved
Address: Room 405, Building 31B, 319 Yueyang Road, Shanghai 200031, China Tel: +86-21-54922832 E-mail: actaps@sinh.ac.cn
沪ICP备05033115号-81
